Spectrophotometric Estimation of Zolpidem in Tablets
نویسندگان
چکیده
A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for the estimation of Zolpidem tartrate in bulk and pharmaceutical dosage forms. Zolpidem tartrate shows maximum absorbance at 238.5 nm with molar absorptivity of 4.4648×10lit/mol/cm. Beer’s law was obeyed in the concentration range of 2-16 μg/ml. The limit of detection and limit of quantification were found to be 0.038152 μg/ml and 0.114577 μg/ml, respectively. Results of analysis were validated statistically and by recovery studies.
منابع مشابه
Validated Spectrophotometric method for the estimation of Zolpidem tartrate in Bulk and Tablet Formulation
Three simple, precise and economical UV spectrophotometric methods have been developed for the estimation of Zolpidem tartrate in bulk and tablet formulations. Zolpidem tartrate has absorbance maxima at 293 nm in zero order spectrum method (Method A ) First order derivative spectra of drug, showed λ maxima = 305 nm and λ minima = 280 nm and amplitude difference was measured for the respective c...
متن کاملApplication of hydrotropic solubilization in spectrophotometric analysis of Esomeprazole and Itopride pharmaceutical combined tablet dosage forms
Two simple, accurate and precise methods for simultaneous estimation of Esomeprazole and Itopride in bulk drug and tablet dosage form have been described. Method-A employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. Method -B is Absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.Beer’s law was obeyed in the con...
متن کاملFormulation and Evaluation of Extended- Release Tablet of Zolpidem Tartrate by Wet Granulation Technique
The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...
متن کاملArtificial Neural Networks (ANN) for the simultaneous spectrophotometric determination of fluoxetine and sertraline in pharmaceutical formulations and biological fluid
Simultaneous spectrophotometric estimation of Fluoxetine and Sertraline in tablets were performed using UV–Vis spectroscopic and Artificial Neural Networks (ANN). Absorption spectra of two components were recorded in 200–300 (nm) wavelengths region with an interval of 1 nm. The calibration models were thoroughly evaluated at several concentration levels using the spectra of synthetic binary mix...
متن کاملArtificial Neural Networks (ANN) for the simultaneous spectrophotometric determination of fluoxetine and sertraline in pharmaceutical formulations and biological fluid
Simultaneous spectrophotometric estimation of Fluoxetine and Sertraline in tablets were performed using UV–Vis spectroscopic and Artificial Neural Networks (ANN). Absorption spectra of two components were recorded in 200–300 (nm) wavelengths region with an interval of 1 nm. The calibration models were thoroughly evaluated at several concentration levels using the spectra of synthetic binary mix...
متن کامل